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Scrambler Therapy for Corticobasal Syndrome-Associated Pain

Exploring new therapy for pain relief in corticobasal syndrome.

Recruiting
50-89 years
All
Phase N/A

This study tests if Scrambler Therapy (ST) helps reduce pain in people with corticobasal syndrome (CBS), a rare brain disorder causing movement problems and pain. Pain from CBS can get worse over time. The study compares ST to Transcutaneous Electrical Nerve Stimulation (TENS), a method using mild electrical signals to relieve pain. Participants will first receive TENS or ST and eventually all will try ST. They will have electrodes placed on their skin near painful areas and receive treatment for 30-40 minutes until pain is relieved.

  • Study length: 1 month
  • Participants must be 50+ years old with CBS and pain score above 4/10
  • People with certain medical devices or conditions cannot join

The study's goal is to see if ST can reduce pain by 33% in a month, which may lead to larger studies. It offers a chance to try a new pain treatment without medication.

Study details
    Corticobasal Degeneration
    Corticobasal Syndrome
    Pain
    Neuropathic

NCT05653778

Johns Hopkins University

17 April 2026

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