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Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Studying abdominal compression for treating low blood pressure in autonomic failure.

Recruiting
18-80 years
All
Phase 1

In this study, researchers are investigating how abdominal compression can help improve blood pressure for people with orthostatic hypotension due to autonomic failure. Orthostatic hypotension means a person experiences low blood pressure when they stand up, often causing dizziness. Autonomic failure happens when the part of the nervous system that controls blood pressure doesn't work properly. Compression garments, like tight clothing around the abdomen, might help by squeezing the body to raise blood pressure. This study compares compression garments with midodrine, a medicine usually given for this condition. Participants will try two different types of compression on a special table that tilts them to see which works better.

  • Study involves two separate days of testing.
  • Participants must be between 18-80 years old.
  • People with heart, kidney, or liver problems cannot join.
Study details
    Orthostatic Hypotension
    Pure Autonomic Failure
    Multiple System Atrophy
    Autonomic Failure

NCT02429557

Vanderbilt University Medical Center

17 April 2026

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