This study is testing a new drug called dapansutrile for people with Parkinson's disease (PD), a condition that affects the brain and causes movement problems. PD involves inflammation, which is when parts of the body become swollen and sore. This trial checks if dapansutrile, which helps reduce inflammation, is safe and works well for PD.

Participants will take either dapansutrile or a placebo (a fake medicine) daily for 6 months. Afterward, everyone can choose to take dapansutrile for another 6 months. Researchers will monitor safety and check for changes in symptoms and inflammation in the brain and blood.

• Duration: 6 months with an optional extra 6 months.
• Visits: Regular check-ups, blood tests, brain scans, and a lumbar puncture (a procedure to collect fluid from the spine).
• Eligibility: Participants must be aged 50-80, have early-stage PD, and meet other health requirements.

This study aims to find out if dapansutrile can safely help reduce inflammation and improve PD symptoms.