This study aims to better understand the genetic causes of Parkinson's Disease (PD). PD is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Researchers will collect samples from people with PD and some with REM Sleep Behavior Disorder (RBD), a sleep condition that can be linked to PD. They'll study the whole genome, meaning all of a person's DNA, to find rare changes in genes that might cause these diseases. They will also use iPSC technology. This means they will take a type of blood cell and turn it into stem cells, which can become any cell in the body, to study the disease further.

• The study will involve about 200 patients and will include blood sampling.
• Participation requires outpatient visits and signing an informed consent.
• The research could help create genetic tests for predicting PD.

People eligible to take part are those with certain PD symptoms or with RBD. Some conditions, like other brain diseases or certain drug uses, could exclude someone from joining. The study takes place in Italy and involves multiple hospitals working together.