**Parkinson's Disease (PD)** is a brain disorder that affects movement. This study tests different treatments to find which works best for people with PD. The trial is called a Multi-Arm, Multi-Stage (MAMS) trial, meaning multiple treatments are tested at once in separate groups called "arms". A treatment is compared to a placebo, which is like a sugar pill that has no medicine, to see how well it works. Regular checks, called interim analyses, help decide if a treatment should continue or stop. The trial will last up to 36 months and involve both in-person and remote visits.

• Participation may last up to 3 years with several remote check-ins every 6 months.
• Two initial treatment options are telmisartan and terazosin, with a placebo group for comparison.
• Participants are informed about the study's progress and results are shared online and in medical journals.

Note: To join, you need a PD diagnosis, must be on certain PD medications, and meet other specific health requirements. Pregnant or breastfeeding women and those with certain health conditions cannot participate.