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Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Exploring Parkinson's impact on thinking and memory through brain research.

Recruiting
40 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates brain activity in people with Parkinson's disease, a condition affecting movement and thinking. Researchers focus on understanding cognitive impairment (trouble with memory and thinking) by examining activity in the brain during surgery called Deep Brain Stimulation (DBS). DBS involves placing electrodes in the brain to help control symptoms. In this study, recordings will be taken from corticostriatal structures – parts of the brain involved in thinking and movement. Participants must be 40 or older, diagnosed with Parkinson's, and scheduled for DBS surgery at Vanderbilt University. They should be able to follow instructions during the surgery and speak English. People with other movement disorders or those under 40 are not eligible.

  • Participation involves undergoing DBS surgery.
  • Must be able to understand and follow instructions during surgery.
  • Focuses on non-motor symptoms related to Parkinson's.
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Study details
    Parkinson Disease

NCT04715984

Vanderbilt University Medical Center

17 April 2026

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