This study explores whether tenofovir disoproxil fumarate (a medication) helps with Parkinson's disease, a condition affecting movement. The study looks at changes in motor symptoms (like shaking or stiffness) and any side effects in patients with early Parkinson's disease. Researchers will compare patients taking tenofovir to those not taking it at different times.

Eligibility: Participants must have Parkinson's disease, with a Hoehn Yahr stage of 1 to 2.5, which means early and mild symptoms. They should also have a Mini-Mental State Examination (MMSE) score of 24 or higher, indicating normal memory and thinking skills.

Exclusions: People with other neurological disorders, past brain surgeries, or abnormal liver and kidney functions cannot join. Those with chronic hepatitis B, HIV, severe mental health issues, other serious health conditions, or allergies to the drug are also excluded. Pregnant or breastfeeding women and those over 65 cannot participate.

• This study involves monitoring changes in movement and side effects.
• Participants must be in the early stages of Parkinson's disease.
• Certain health conditions and age restrictions apply.