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CANadian Adaptive DBS TriAl

Join a study for adaptive DBS in Parkinson's treatment.

Recruiting
18-80 years
All
Phase N/A

Parkinson's disease (PD) is a condition that affects movement, causing symptoms like freezing of gait (FOG), where you feel stuck and can't move your feet, and hypophonia, which is a soft voice. These symptoms often don't improve or can even worsen with a treatment called deep brain stimulation (DBS). DBS involves using an implant to send electric signals to the brain. In this study, we are comparing two types of DBS: continuous DBS (cDBS) and adaptive DBS (aDBS). Adaptive DBS uses information from the brain to automatically adjust the treatment, which might help with movement and speech issues better than continuous DBS.

  • The study lasts for two phases and is double-blinded, meaning neither doctors nor patients know which treatment is being given at any time.
  • Participants need to have their DBS device replaced due to battery life, and have issues with walking, balance, or speech worsened by current DBS.
  • Requirements include using Medtronic products and being able to understand and follow the study guidelines.
Study details
    Parkinson Disease

NCT05402163

University of Toronto

17 April 2026

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