The Swedish BioFINDER 2 Study will explore brain changes in Alzheimer’s disease (AD) and other dementias. Dementia is a condition that affects memory, thinking, and social abilities, and AD is a common type of dementia. The study uses advanced techniques like tau-PET and amyloid-PET scans to track changes in certain brain proteins that are linked to dementia. These scans help scientists see how these proteins spread in the brain over time. Participants will also have cognitive tests to check memory and thinking skills.

• Participants will have various tests like MRI, PET scans, and spinal fluid analysis.
• Some tests might be uncomfortable, like lumbar puncture (spinal tap), but provide important info.
• Participants are grouped by age and cognitive health (healthy adults, those with minor memory concerns, and those with dementia).

This study aims to improve early diagnosis and treatment for dementia by understanding brain changes better. It is important for participants to be comfortable with medical tests and able to follow instructions in Swedish.