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Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease

Studying dopamine signals in healthy and Parkinson's brains.

Recruiting
35 years and older
All
Phase N/A

This study looks at how the brain's *dopamine* signals work in healthy people and people with Parkinson's Disease (PD). Dopamine is a chemical in the brain that helps with movement and feeling happy. The study will check if there are differences in *optimistic* (expecting good things) and *pessimistic* (expecting bad things) signals in people with and without PD. It uses MRI (Magnetic Resonance Imaging, a type of scan) to see how the brain reacts when people play a game to win money. People with PD will be tested on and off their medication to see how it affects them.

  • The study involves 1-2 visits where participants play games in an MRI scanner.
  • People need to be 35 or older and meet certain health criteria to join.
  • Participants will not take their regular medication before one visit.
Study details
    Healthy
    Parkinson
    Medication Administration

NCT07402928

Danish Research Centre for Magnetic Resonance

17 April 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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