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Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Studying brain stimulation effects on language in neurodegenerative diseases.

Recruiting
60-80 years
All
Phase N/A

This study explores how a special technique called temporal interference stimulation (TIS) affects language skills in people with neurodegenerative diseases like Parkinson's. TIS is a non-painful method that uses gentle electrical currents to target a part of the brain involved in language. The study is designed as a cross-over, meaning participants will receive both real TIS and a fake version, in random order. Each session lasts about 20 minutes, during which participants will do language tasks. Brain scans, called fMRI, will be done before and after to check changes in brain activity.

  • The study involves just one session for each type of stimulation.
  • Participants will be asked to complete language tasks.
  • This study is for those with mild memory issues related to specific neurodegenerative diseases.

People with severe psychiatric disorders, other brain diseases, or metal in their bodies can't join. Participating might help scientists understand more about treating communication problems in these conditions.

Study details
    Mild Cognitive Impairment (MCI) Amnestic
    Lewy Body Disease With Mild Cognitive Impairment
    Parkinson's Disease With Mild Cognitive Impairment

NCT07449117

Masaryk University

17 April 2026

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