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Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

Exploring nerve grafts for Parkinson's-related conditions in a clinical trial.

Recruiting
40-75 years
All
Phase 1

This study explores a unique approach to treating Parkinson's Disease (PD) and Multiple System Atrophy (MSA). It involves using a small piece of your own nerve, called the sural nerve, from your leg and placing it into a part of the brain called the substantia nigra. The study aims to see if this can help repair damaged brain cells. Seven participants will join. Four will receive the nerve graft, and three will have a sham surgery (a pretend surgery to compare results). The trial is double-blind, meaning neither the participants nor the researchers know who receives the actual treatment at first. This study helps plan future trials and lasts for one year.

  • Participants must be in the early stages of PD or MSA and aged 40-75.
  • Involves surgery and follow-up visits for one year.
  • Participants might receive a placebo surgery.
Study details
    Multiple System Atrophy
    Parkinsons Disease

NCT06683365

Craig van Horne, MD, PhD

5 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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