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The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism

Join our NADAPT Study on NAD Therapy for Atypical Parkinsonism!

Recruiting
30-85 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is about testing a treatment for certain brain diseases that get worse over time. The diseases are called Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These are serious conditions that affect movement and thinking. They are rare and currently have no cure. The study is trying to find out if a vitamin-like substance called Nicotinamide Riboside (NR) can help. NR is thought to boost a chemical in the brain called NAD, which might protect brain cells and slow down the disease.

This study will last about 18 months, and it involves taking either NR or a placebo (a pill with no active medicine) every day. Participants will have regular check-ups and report on their health from home.

  • Participants will be from Norway and need to visit clinics during the study.
  • The study involves taking a daily dose of 3000mg NR or a placebo.
  • After 18 months, participants can join an extended study to continue taking NR if they wish.
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Study details
    Progressive Supranuclear Palsy
    Multiple System Atrophy
    Corticobasal Syndrome

NCT06162013

Haukeland University Hospital

17 April 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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