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Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

Exploring brain stimulation for memory issues in Parkinson's disease.

Recruiting
21-80 years
All
Phase N/A
Study Summary: This clinical trial is looking at a new way to help people with Parkinson's disease and mild memory problems. Parkinson's disease is a brain disorder that affects movement and sometimes thinking. The study is testing if a combined deep brain stimulation (DBS) approach, which uses tiny electric pulses in the brain, can help with thinking and movement problems. The trial uses two parts of the brain: the Subthalamic Nucleus (STN) and the Nucleus Basalis of Meynert (NBM). Key Points for Participation:
  • This study will last for two years, with check-ups every six months.
  • Ten participants will be involved and will have surgery to place four DBS leads in the brain.
  • Participants must have Parkinson's disease and may need to stop some medications for the study.
The study will include different tests and tasks to see how well the treatment works. People who have dementia or certain health problems, or who are pregnant, cannot join. The goal is to see if this new treatment is safe and if it helps with thinking and movement in Parkinson's.
Study details
    Parkinson's Disease
    Mild Cognitive Impairment

NCT05968703

Helen M. Bronte-Stewart

17 April 2026

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