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CPAP for the Treatment of Supine Hypertension

Exploring CPAP for managing high blood pressure while lying down.

Recruiting
40-80 years
All
Phase N/A
Study Overview: This study examines if using Continuous Positive Airway Pressure (CPAP) can help treat high blood pressure in people lying down due to autonomic failure, a condition affecting automatic body functions like blood pressure control. CPAP is commonly used to treat sleep apnea, a condition where breathing stops and starts during sleep. In this study, a CPAP machine gently blows air into a mask over the nose or mouth to keep the airways open. Participants will spend 3-5 days at Vanderbilt Clinical Research Center. The study includes a mix of daytime and overnight sessions. Daytime sessions involve 2 study days with CPAP applied for up to 2 hours, while overnight sessions involve 3 study nights with CPAP used for up to 9 hours. Key Points:
  • The study lasts 3-5 days with daytime and overnight parts.
  • Participants undergo tests like heart rate and blood pressure checks.
  • Not suitable for those with recent facial injuries or unable to stand for tests.
Study details
    Autonomic Failure
    Pure Autonomic Failure
    Multiple System Atrophy
    Parkinson Disease
    Supine Hypertension
    Neurogenic Orthostatic Hypotension

NCT05489575

Vanderbilt University Medical Center

17 April 2026

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