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Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects

Studying brain changes in new Parkinson's patients using advanced NMR technology.

Recruiting
18-75 years
All
Phase N/A
Study Summary: In this study, scientists are researching how a special brain scanning technique called **Nuclear Magnetic Resonance (NMR) Spectroscopy** can identify changes in brain chemicals in people with early-stage Parkinson’s disease. Parkinson’s disease (PD) affects movement and can cause tremors and stiffness. The study involves a one-time visit to measure brain chemicals using a powerful scanner, **7T MRI**, which provides clearer pictures of the brain than regular MRI. This helps scientists understand how brain chemicals differ between Parkinson’s patients and healthy individuals. Participants will include people with PD who haven't started treatment and healthy people as controls. Key Points:
  • **One-time visit**: The study requires only one visit for brain scanning.
  • **Participants**: People aged 18-75, both with and without Parkinson’s, are included.
  • **No treatment needed**: Patients should not be on any PD medication before participating.
This study helps us learn more about Parkinson's and could lead to better treatments in the future.
Study details
    Parkinson's Disease

NCT04735172

University Hospital, Clermont-Ferrand

17 April 2026

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