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Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Investigating Modified Immune Cells for Advanced Melanoma and Metastatic Tumors

Recruiting
18-75 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates stage IIIC or IV melanoma and metastatic solid tumors. The purpose of this study is to understand how gene-modified immune cells, specifically IL13Ralpha2 CAR T cells, interact with these conditions.

The study evaluates the safety of these modified immune cells and their ability to remain in the body and target cancer cells. The focus is on assessing the safety and effectiveness of this treatment approach.

  • Who can participate: Adults aged 18 to 74 with stage IIIC or IV melanoma or other metastatic solid tumors may qualify if tumors express IL13Ralpha2 and specific health criteria are met.
  • Study details: Participants will receive modified immune cells called IL13Ralpha2 CAR T cells. Some may also receive a placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine.
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Study details
    Metastatic Malignant Solid Neoplasm
    Metastatic Melanoma
    Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
    Pathologic Stage IV Cutaneous Melanoma AJCC v8
    Recurrent Malignant Solid Neoplasm
    Refractory Malignant Solid Neoplasm
    Uveal Melanoma
    Acral Melanoma
    Neuroendocrine Tumors
    Paraganglioma
    Pheochromocytoma
    Adrenocortical Carcinoma
    Pancreatic Neuroendocrine Tumor
    Thyroid Cancer
    Breast Cancer
    Lung Adenocarcinoma
    Head and Neck Squamous Cell Carcinoma

NCT04119024

Anusha Kalbasi

30 July 2026

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