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Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels

Investigating Treatments in Metastatic Foregut Adenocarcinoma

Recruiting
18-80 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates metastatic foregut adenocarcinoma. It compares the effects of standard care therapy with and without additional treatments.

The study evaluates the safety and effectiveness of adding specific interventions to standard care for patients with this condition.

  • Who can participate: Adults aged 18 to 80 with certain types of metastatic foregut adenocarcinoma can participate. Key factors include having a resectable primary tumor and limited metastatic disease.
  • Study details: Participants will receive standard care therapy, with some also undergoing additional treatments. A placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine, may be used in the study.
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Study details
    Foregut Adenocarcinoma
    Esophageal Adenocarcinoma
    Gastroesophageal Adenocarcinoma
    Gastric Adenocarcinoma
    Pancreas Adenocarcinoma
    Duodenal Adenocarcinoma
    Ampullary Adenocarcinoma
    Gallbladder Adenocarcinoma
    Intra - and Extrahepatic Cholangiocarcinoma

NCT07282912

Yale University

12 September 2026

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