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Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Investigating the Safety and Effectiveness of an Investigational Medication with Radiotherapy for Locally Advanced Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1/2

This study investigates the use of an investigational medication in combination with hypofractionated radiation therapy for treating locally advanced pancreatic cancer. The purpose is to explore the safety and effectiveness of this combination in patients whose cancer has spread to nearby tissues or lymph nodes.

The study evaluates how well the investigational medication works with radiation therapy. It focuses on understanding the safety and tolerability of this combination and how it affects progression-free survival compared to radiation therapy alone.

  • Who can participate: Adults aged 18 or older with confirmed locally advanced pancreatic adenocarcinoma, who have completed a specific chemotherapy regimen, may participate. Participants should have measurable disease and meet certain health criteria.
  • Study details: Participants will receive either the investigational medication or a placebo along with radiation therapy. A placebo is an inactive substance that looks like the investigational medicine but does not contain any medicine.
Study details
    Locally Advanced Pancreatic Adenocarcinoma
    Stage III Pancreatic Cancer AJCC v8

NCT04172532

National Cancer Institute (NCI)

17 October 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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