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A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Research Study for Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 1

This study investigates advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. The purpose of this study is to explore the safety and effects of an investigational medication called an antibody drug conjugate (ADC).

The study evaluates how well the investigational medication works in targeting and affecting cancer cells. It focuses on understanding its safety and effectiveness for participants with these advanced cancers.

  • Who can participate: Participants must be 18 years or older with advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. They should have measurable disease and an ECOG Performance status of 0-1.
  • Study details: Participants will receive the investigational medication through an intravenous infusion.
Study details
    Advanced/Metastatic Solid Tumors
    Bladder Cancer
    Urothelial Carcinoma
    Advanced Non-Small Cell Lung Cancer
    Carcinoma
    Non Small Cell Lung
    Carcinoma
    Squamous Cell of Head and Neck
    Head and Neck Cancer
    Esophageal Cancer
    Gastroesophageal Junction Adenocarcinoma
    Esophageal Squamous Cell Carcinoma
    Esophageal Adenocarcinoma
    Pancreatic Adenocarcinoma
    Pancreatic Cancer

NCT07090499

Pfizer

17 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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