This study investigates pancreatic ductal adenocarcinoma. It looks into whether removing para-aortic lymph nodes during pancreaticoduodenectomy should be a standard part of the procedure.

The focus of this study is to evaluate the impact of including para-aortic lymph node removal on patient outcomes. It examines whether this addition to the standard procedure affects patient prognosis.

• Who can participate: Adults diagnosed with pancreatic ductal adenocarcinoma in the head of the pancreas, who are eligible for upfront pancreaticoduodenectomy with standard lymphadenectomy, can participate.
• Study details: Participants will undergo pancreaticoduodenectomy with or without the removal of para-aortic lymph nodes. The study will compare outcomes of these approaches. A placebo is not involved in this study.