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Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI

Investigating the Effectiveness of Investigational Medication for Non-Colorectal/Non-Endometrial Cancers With dMMR/MSI

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the effectiveness of an investigational medication for treating non-resectable metastatic or locally advanced non-colorectal and non-endometrial cancers with deficient mismatch repair (dMMR) or microsatellite instability (MSI).

The study evaluates the safety and effectiveness of this investigational medication compared to standard chemotherapy treatments in adult patients with specific types of advanced cancers.

  • Who can participate: Adults aged 18 and older with certain advanced cancers that are dMMR/MSI positive may participate. Key eligibility includes having no prior systemic treatment for metastatic disease and confirmed dMMR/MSI status.
  • Study details: Participants will receive either the investigational medication or standard chemotherapy. Those on chemotherapy may switch to the investigational medication if their disease progresses.
  • Study timelines: The study will last up to 24 months.
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Study details
    Pancreatic Adenocarcinoma
    Ampulla of Vater Carcinoma
    Adrenocortical Carcinoma
    Neuroendocrine Carcinoma
    Soft Tissue Sarcoma
    Small Bowel Adenocarcinoma
    Duodenum Adenocarcinoma
    Gastric Adenocarcinoma

NCT06333314

UNICANCER

30 July 2026

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