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Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

Investigating Safety and Tolerability of Adding Epidermal Growth Factor Receptor Blockers to Chemotherapy in Advanced Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates advanced pancreatic cancer. The purpose of this study is to explore whether adding a low dose of EGFR blocking drugs to the standard chemotherapy regimen is safe and tolerable for patients with this condition.

Researchers will evaluate the safety and effectiveness of the treatment combination. They will monitor long-term outcomes such as overall survival and tumor response to the treatment.

  • Who can participate: Adults aged 18 years and older with advanced pancreatic cancer may be eligible. Participants must have a specific performance status and consent to a pre-study biopsy if needed.
  • Study details: Participants will receive a combination of chemotherapy and an investigational medication. Some may receive a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.
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Study details
    Pancreatic Adenocarcinoma
    Metastatic Pancreatic Cancer
    Basal Cell Neoplasm

NCT06483555

UNC Lineberger Comprehensive Cancer Center

30 July 2026

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