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Master Protocol of TCR-modified T Cell Therapy Targeting HLA-restricted KRAS Antigen Administered in Adult Patients With Metastatic or Locally Advanced PDAC

Investigating T Cell Therapy for Metastatic or Locally Advanced PDAC

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates TCR-modified T cell therapy in patients with metastatic or locally advanced PDAC. The purpose is to explore how these engineered T cells can recognize specific tumor antigens and potentially activate an immune response.

The study evaluates the safety and clinical activity of these T cells. It focuses on understanding how well the therapy works and its effects on patients' health.

  • Who can participate: Adults aged 18 or older with metastatic or locally advanced PDAC can participate. Participants must have confirmed KRAS mutations and meet specific health criteria.
  • Study details: Participants will receive T cell therapy targeting specific tumor antigens.
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Study details
    PDAC

NCT07145450

Anocca AB

31 July 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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