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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Study of Investigational Medication for Solid Tumors with Genetic Mutations

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates solid tumors in patients with BRCA1/2, PALB2, or homologous recombination deficiency (HRD) mutations. The purpose of this study is to determine the tolerable dose of the investigational medication for future trials.

The study evaluates the safety and tolerability of the investigational medication. It also looks at how the medication affects quality of life and investigates changes in specific genetic markers.

  • Who can participate: Adults aged 18 and older with confirmed solid tumors and specific genetic mutations, such as BRCA1/2, PALB2, or HRD, may participate. Participants must have a performance status of 2 or less and meet certain health criteria.
  • Study details: Participants will receive the investigational medication through an IV infusion. Some may receive a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.
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Study details
    Advanced Solid Tumor

NCT04890613

Senhwa Biosciences, Inc.

31 July 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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