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A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Investigation of an Investigational Medication for HER2 Mutations in Solid Tumors

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates solid tumors with mutations in the human epidermal growth factor receptor 2 (HER2).

The study evaluates the safety and effectiveness of an investigational medication in participants with solid tumors that have HER2 mutations.

  • Who can participate: Adults aged 18 and older with certain solid tumors, such as colorectal carcinoma and biliary tract cancer, excluding non-small cell lung cancer, may participate. Participants must have a documented HER2 mutation and have tried standard treatments or have no other satisfactory options.
  • Study details: Participants will take an investigational medication by mouth in cycles of 3 weeks. A placebo is not used in this study.
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Study details
    Advanced Solid Tumors
    HER2 Mutation

NCT06760819

Bayer

12 September 2026

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