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Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

Chemotherapy With or Without Investigational Medication for Advanced Pancreatic Cancer

Recruiting
18 years and older
All
Phase 3

The purpose of this study is to investigate advanced pancreatic cancer without KRAS mutations. This study evaluates the effect of adding an investigational medication to standard chemotherapy in patients with this condition.

This study evaluates the safety and effectiveness of the treatment. It focuses on understanding how the investigational medication works with standard chemotherapy in improving overall survival and other health outcomes.

  • Who can participate: Participants must be 18 years or older with confirmed advanced pancreatic cancer without KRAS mutations and have received prior chemotherapy.
  • Study details: Participants will receive either standard chemotherapy alone or with an investigational medication. A placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine, may be used for comparison.
Study details
    Locally Advanced Pancreatic Adenocarcinoma
    Metastatic Pancreatic Adenocarcinoma
    Stage III Pancreatic Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8
    Unresectable Pancreatic Adenocarcinoma

NCT06998940

SWOG Cancer Research Network

31 July 2026

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