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Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma

Study on Preoperative Treatment for Borderline Resectable Pancreatic Adenocarcinoma

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

The purpose of this study is to investigate borderline resectable pancreatic adenocarcinoma.

This study evaluates the impact and effectiveness of adding high-dose stereotactic body radiotherapy to preoperative chemotherapy. It seeks to understand if this combination can improve treatment outcomes for patients.

  • Who can participate: Adults over 18 years with a confirmed diagnosis of pancreatic adenocarcinoma that is borderline resectable can participate. Participants must have good performance status and meet specific health criteria, including no prior treatment for pancreatic cancer.
  • Study details: Participants will receive chemotherapy before surgery. Some will also receive high-dose radiotherapy. A placebo is not used in this study.
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Study details
    Pancreatic Neoplasm
    Pancreatic Adenocarcinoma
    Borderline Resectable Pancreatic Adenocarcinoma

NCT05083247

Erasme University Hospital

8 April 2026

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