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Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer

Investigational Vaccine Combinations for Resectable Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1/2

This study investigates pancreatic cancer. The purpose of this study is to evaluate the safety and clinical activity of two different investigational vaccines used in combination with other treatments for individuals with surgically resectable pancreatic adenocarcinoma.

The study focuses on determining how safe these investigational vaccines are and how well they work when used together with other treatments. It evaluates the safety and effectiveness of these combinations in individuals with pancreatic cancer.

  • Who can participate: Adults diagnosed with pancreatic adenocarcinoma that can be surgically removed may join. Participants should have a good performance status and must not have received any prior anti-cancer immunotherapy.
  • Study details: Participants will receive investigational vaccines in combination with other treatments. Some may receive a placebo, which is an inactive substance that looks like the investigational vaccine but does not contain any medicine.
Study details
    Pancreatic Cancer

NCT06782932

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

31 July 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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