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Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors

Investigational CAR-NK Cell Therapy Research Study for Advanced Solid Tumors

Recruiting
8-85 years
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates advanced solid tumors. The purpose of this study is to evaluate the safety and feasibility of using CAR-NK cells derived from healthy donors.

The study evaluates the effectiveness of using CAR-NK cells in targeting specific antigens found in tumors. It looks at how well these modified cells work in treating tumors.

  • Who can participate: Adults aged 18 to 75 years with advanced solid tumors that cannot be removed by surgery may qualify. Participants must have a tumor with specific targetable antigens.
  • Study details: Participants will receive CAR-NK cells derived from donors after undergoing chemotherapy to prepare their bodies.
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Study details
    Cancer
    Breast Cancer
    Non-Small Cell Lung Cancer (NSCLC)
    Colorectal Cancer (Locally Advanced or Metastatic)
    Prostate Cancer - Recurrent
    Pancreatic Ductal Adenocarcinoma (PDAC)
    Ovarian Cancer
    Glioblastoma
    Melanoma (Skin Cancer)
    Acute Myeloid Leukemia (AML)
    Non Hodgkin Lymphoma
    Multiple Myeloma (MM)
    Lymphoma
    Large B-Cell
    Diffuse (DLBCL)
    Lymphoma
    Liver Cancer

NCT07410494

Essen Biotech

31 July 2026

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