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Familial Investigations of Childhood Cancer Predisposition

Genetic Study in Families with Cancer History

Recruiting
All
Phase N/A

The purpose of this study is to explore familial cancer. It investigates genetic factors that may contribute to cancer development in families with a history of the condition.

The study focuses on identifying genetic variants that could be linked to familial cancer. It evaluates these variants to enhance understanding and potentially improve diagnosis and care for hereditary cancer.

  • Who can participate: Individuals with a history of cancer diagnosed under 26 years of age and relatives with early-onset cancer may participate. Those with multiple cancers or rare pediatric cancers, and their family members, are also eligible.
  • Study details: Participants will provide blood, saliva, or skin samples for genetic analysis. These samples are stored for study purposes, and leftover tumor samples may also be analyzed. A placebo is not involved in this study.
Study details
    Acute Leukemia
    Adenomatous Polyposis
    Adrenocortical Carcinoma
    AML
    BAP1 Tumor Predisposition Syndrome
    Carney Complex
    Choroid Plexus Carcinoma
    Constitutional Mismatch Repair Deficiency Syndrome
    Diamond-Blackfan Anemia
    DICER1 Syndrome
    Dyskeratosis Congenita
    Emberger Syndrome
    Familial Acute Myeloid Leukemia
    Familial Adenomatous Polyposis
    Fanconi Anemia
    Familial Cancer
    Familial Wilms Tumor
    Familial Neuroblastoma
    GIST
    Hereditary Breast and Ovarian Cancer
    Hereditary Paraganglioma-Pheochromocytoma Syndrome
    Hodgkin Lymphoma
    Juvenile Polyposis
    Li-Fraumeni Syndrome
    Lynch Syndrome
    MDS
    Melanoma Syndrome
    Multiple Endocrine Neoplasia Type 1
    Multiple Endocrine Neoplasia Type 2
    Neuroblastoma
    Neurofibromatosis Type 1
    Neurofibromatosis Type II
    Nevoid Basal Cell Carcinoma Syndrome
    Non Hodgkin Lymphoma
    Noonan Syndrome and Other Rasopathy
    Overgrowth Syndromes
    Pancreatic Cancer
    Peutz-Jeghers Syndrome
    Pheochromocytoma/Paraganglioma
    PTEN Hamartoma Tumor Syndrome
    Retinoblastoma
    Rhabdoid Tumor Predisposition Syndrome
    Rhabdomyosarcoma
    Rothmund-Thomson Syndrome
    Tuberous Sclerosis
    Von Hippel-Lindau Disease

NCT03050268

St. Jude Children's Research Hospital

30 July 2026

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