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Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer

Investigational Therapy for Advanced Pancreatic Cancer

Recruiting
21-90 years
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates advanced pancreatic cancer. The purpose of this study is to evaluate a dual-target CAR-T cell therapy for this condition.

The study evaluates the safety and effectiveness of CAR-T cell therapy targeting two specific proteins found in pancreatic cancer cells. This approach is being assessed for its potential to manage the disease.

  • Who can participate: Adults with advanced pancreatic cancer who have tried or cannot tolerate standard treatments may qualify. Participants need to have a good performance status and meet specific health criteria.
  • Study details: Participants will receive two separate CAR-T cell infusions after chemotherapy. A placebo may be used for comparison.
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Study details
    Pancreatic Cancer
    Pancreatic Carcinoma
    Pancreatic Cancer Non-resectable
    Pancreatic Cancer Stage IV

NCT07066995

Essen Biotech

31 July 2026

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