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Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

Investigational Study on a Specific Enzyme Inhibition in Advanced Cancer Treatment

Recruiting
18 years and older
All
Phase 1/2

This study investigates a condition related to CD73 enzyme activity. The purpose of this study is to evaluate how this investigational medication works alone and in combination with other treatments.

The study will generally focus on assessing the safety and tolerability of the investigational medication. It will also look at how well the medication works in treating the condition.

  • Who can participate: Adults with advanced or metastatic solid tumors, such as NSCLC and PDAC, may be eligible. Participants should have measurable lesions and meet other health criteria.
  • Study details: Participants will receive either the investigational medication alone or in combination with other treatments. A placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine, may be used in the study.
Study details
    Non Small Cell Lung Cancer
    Pancreatic Ductal Adenocarcinoma

NCT05431270

Phanes Therapeutics

31 July 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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