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A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Study of Investigational Treatment for Stomach, Gastroesophageal Junction, or Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1

This study investigates stomach cancer, gastroesophageal junction cancer, and pancreatic cancer. It examines how an investigational medication, ASP2138, interacts with these conditions.

This study evaluates the safety and tolerability of ASP2138, both alone and in combination with standard cancer treatments. Researchers seek to find a suitable dose and assess any potential medical issues from the treatments.

  • Who can participate: Adults 18 years or older with locally advanced, unresectable, or metastatic stomach, gastroesophageal junction, or pancreatic cancer can participate, provided their tumor has the CLDN18.2 marker.
  • Study details: Participants will receive ASP2138 either alone or with standard cancer treatments. The study includes different phases to determine the best dose. A placebo is not involved in this study.
Study details
    Gastric Adenocarcinoma
    Gastroesophageal Junction (GEJ) Adenocarcinoma
    Pancreatic Adenocarcinoma

NCT05365581

Astellas Pharma Global Development, Inc.

12 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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