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VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Investigational Treatment for Solid Tumors and Lymphoma

Recruiting
18-80 years
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates TrkA overexpression in solid tumors and lymphoma. The purpose of this study is to explore the effects of an investigational medication alone and in combination with another treatment.

The study evaluates the safety and effectiveness of the investigational medication. Researchers are looking at how the body responds to the treatment and any side effects that may occur.

  • Who can participate: Adults with confirmed solid tumor or lymphoma driven by specific genetic markers, with no other treatment options, can participate. Participants must have good performance status and be able to take oral medication.
  • Study details: Participants will take the investigational medication by mouth. In some cases, it will be combined with another treatment.
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Study details
    Head and Neck Carcinoma
    Adenoid Cystic Carcinoma
    Lung Cancer
    Non-Small Cell Lung Cancer
    Pancreatic Cancer
    Mesothelioma
    Esophageal Cancer
    Any Solid Tumors Progressed After a Prior Immunotherapy
    Head and Neck Squamous Cell Carcinoma
    Head and Neck Squamous Cell Carcinoma HNSCC
    Salivary Gland Carcinomas
    Head and Neck Cancers - Salivary Gland
    Head and Neck Cancers - Nasopharyngeal
    Head and Neck Cancers - Throat
    Small Cell Lung Cancer ( SCLC )
    Lung Cancer (Locally Advanced or Metastatic)
    Head and Neck Cancers - Tonsils
    Head and Neck Cancers Hypopharynx
    Head and Neck Cancers Larynx
    Head and Neck Cancers Lip
    Head and Neck Cancers Nasopharynx
    Head and Neck Cancers Oral Cavity
    Head and Neck Cancers
    Head and Neck Cancers Oropharynx
    Head and Neck Cancers Trachea

NCT03556228

VM Oncology, LLC

31 July 2026

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