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A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation

Study on Investigational Medication Combined with Cetuximab or Chemotherapy for Solid Tumors

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates solid tumors with the KRAS G12D mutation. The purpose of this study is to explore how an investigational medication works when combined with other treatments.

The study evaluates the safety and effectiveness of the investigational medication when used with cetuximab or chemotherapy. It also looks at how the medication moves through the body and its potential effects.

  • Who can participate: Adults aged 18 years and older with solid tumors may participate. Participants must have failed or be unsuitable for standard treatments and have sufficient organ function.
  • Study details: Participants will receive an investigational medication combined with either cetuximab or chemotherapy.
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Study details
    Advanced Solid Tumors Cancer
    PDAC
    CRC (Colorectal Cancer)

NCT07259590

Genfleet Therapeutics (Shanghai) Inc.

31 July 2026

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