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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Study of Investigational Medication for Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 2

This study investigates the use of an investigational medication in participants with various locally advanced or metastatic solid tumors. The purpose of this study is to explore the effects of this medication in conditions such as melanoma, squamous cell carcinoma of the head and neck, and several other types of cancer.

The study evaluates the safety and effectiveness of the investigational medication. Researchers will also study how the body processes the medication and its relationship with specific protein expressions in tumor tissues.

  • Who can participate: Adults aged 18 and older with advanced or metastatic solid tumors who have received prior treatment may participate. Key eligibility includes having measurable lesions and providing a tumor tissue sample.
  • Study details: Participants will receive the investigational medication and undergo assessments to monitor its effects. Some may receive a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.
Study details
    Advanced Solid Tumor
    Melanoma
    Head and Neck Cancer
    Gastric Cancer
    Ovarian Carcinoma
    Cervical Cancer
    Endometrial Cancer
    Bladder Cancer
    Esophageal Cancer
    Pancreatic Carcinoma
    Prostate Cancer
    Non-small Cell Lung Cancer (NSCLC)
    Lung Cancer
    Breast Cancer

NCT06172478

Daiichi Sankyo

12 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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