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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Study on Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Recruiting
18 years and older
All
Phase 2

This study investigates the use of chemotherapy after surgery in patients with high-risk pancreatic neuroendocrine tumors. The purpose of this study is to explore whether chemotherapy can prevent or delay the return of cancer in these patients.

The study evaluates the safety and effectiveness of chemotherapy in comparison to observation only. It looks at how well patients do without disease recurrence and overall survival.

  • Who can participate: Adults aged 18 and older who have had surgery to remove a well-differentiated pancreatic neuroendocrine tumor may participate. Key eligibility factors include a specific Ki-67 test result and recovery from surgery.
  • Study details: Participants will either receive chemotherapy or be monitored without active treatment. Chemotherapy involves taking oral medications. A placebo is not used in this study.
Study details
    Metastatic Malignant Neoplasm in the Liver
    Pancreatic Neuroendocrine Tumor
    Stage I Pancreatic Neuroendocrine Tumor AJCC v8
    Stage II Pancreatic Neuroendocrine Tumor AJCC v8
    Stage III Pancreatic Neuroendocrine Tumor AJCC v8

NCT05040360

SWOG Cancer Research Network

30 July 2026

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