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Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)

Investigating Immunotherapy and Propranolol for Advanced Hepatopancreabiliary Tumors

Recruiting
18 years and older
All
Phase 2

This study investigates the treatment of advanced hepatopancreabiliary tumors. The condition includes pancreatic cancer, hepatocellular carcinoma (HCC), and biliary tract cancer (BTC).

The study evaluates how the combination of immunotherapy and propranolol, with or without chemotherapy, affects these conditions.

  • Who can participate: Participants must be 18 years or older with a body weight over 30 kg. They should have advanced pancreatic adenocarcinoma, hepatocellular carcinoma, or biliary tract cancer that cannot be treated with surgery or local therapy.
  • Study details: Participants will receive a combination of investigational medications and propranolol. A placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine, may be used in this study.
Study details
    Pancreatic Cancer
    Hepatocellular Cancer
    Biliary Tract Cancer
    Cholangiocarcinoma

NCT05451043

AHS Cancer Control Alberta

30 July 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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