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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Study on Investigational Medication for NSCLC with Specific Genetic Mutations

Recruiting
18 years and older
All
Phase 2

This study investigates non-small cell lung cancer (NSCLC) with c-Met EXON 14 skip mutations and c-Met dysregulation in advanced solid tumors. The purpose of this study is to explore how the investigational medication works with these specific genetic changes in cancer.

The study evaluates the safety, effectiveness, and tolerability of the investigational medication. Researchers are looking at various types of tumors to understand how the medication affects them.

  • Who can participate: Adults aged 18 and older with specific genetic markers related to c-Met in their cancer may be eligible. Participants must have a measurable lesion and meet specific health criteria.
  • Study details: Participants will take the investigational medication, which may be combined with other treatments. Some may receive a placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine.
Study details
    Solid Tumors
    Advanced Cancer
    Renal Cancer
    Gastric Cancer
    Gastroesophageal Junction Adenocarcinoma
    NSCLC
    Lung Cancer
    Brain Tumor
    Glioblastoma Multiforme
    EGFR Gene Mutation
    MET Amplification
    HGF
    Thyroid Cancer
    Pancreatic Cancer
    Colon Cancer
    MET Alteration
    MET Fusion
    Exon 14 Skipping

NCT03175224

Apollomics Inc.

30 July 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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