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Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

Study of Investigational Combination of Medications for Advanced and Refractory Solid Tumors

Recruiting
18 years and older
All
Phase 1/2

This study investigates advanced or refractory solid tumors. It evaluates the effects of a combination of investigational medications on these conditions.

The study focuses on evaluating the safety and effectiveness of the investigational medication combination. It looks at how these medications work together to affect the condition.

  • Who can participate: Adults aged 18 and older with advanced or refractory solid tumors can participate. Participants must have measurable disease and have undergone at least one standard treatment for metastatic disease.
  • Study details: Participants will take investigational medications by mouth. Some may receive a placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine.
Study details
    Advanced Malignant Solid Neoplasm
    Locally Advanced Pancreatic Carcinoma
    Metastatic Pancreatic Carcinoma
    Refractory Malignant Solid Neoplasm
    Refractory Pancreatic Carcinoma
    Stage II Pancreatic Cancer AJCC v8
    Stage III Pancreatic Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8
    Unresectable Pancreatic Carcinoma

NCT05053971

National Cancer Institute (NCI)

31 July 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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