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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Investigating Maintenance Therapy with Investigational Medication in Resected Pancreatic Cancer with BRCA1, BRCA2, or PALB2 Mutations

Recruiting
18 years and older
All
Phase 2

This study investigates pancreatic cancer with a focus on patients who have undergone surgery and chemotherapy. The purpose of this study is to explore the effects of an investigational medication following these treatments in patients with specific genetic mutations.

The study evaluates the safety and effectiveness of the investigational medication. It examines how well the medication works in maintaining health after surgery and chemotherapy in patients with pancreatic cancer.

  • Who can participate: Adults aged 18 and older with pancreatic cancer, who have had surgery and chemotherapy, may be eligible if they have a specific genetic mutation.
  • Study details: Participants will take an investigational medication or a placebo, which looks like the investigational medication but contains no active ingredients. They will have regular check-ups and tests during the study.
Study details
    Pancreatic Acinar Cell Carcinoma
    Pancreatic Adenosquamous Carcinoma
    Pancreatic Squamous Cell Carcinoma
    Resectable Pancreatic Acinar Cell Carcinoma
    Resectable Pancreatic Adenocarcinoma
    Resectable Pancreatic Adenosquamous Carcinoma
    Resectable Pancreatic Carcinoma

NCT04858334

National Cancer Institute (NCI)

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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