This study investigates pain control methods following pancreatoduodenectomy. The study compares two pain relief techniques: rectus sheath block with liposomal bupivacaine and thoracic epidural analgesia.

The purpose of this study is to evaluate whether rectus sheath blocks with liposomal bupivacaine are as effective as thoracic epidural analgesia for pain management. It focuses on assessing the effectiveness of these pain control methods in a non-inferior manner.

• Who can participate: Adults aged 18 and older undergoing open pancreaticoduodenectomy at the University of Minnesota can participate. Key eligibility factors include no contraindication to block placement, no chronic opioid use, and the ability to understand the recovery survey.
• Study details: Participants will either receive a rectus sheath block with liposomal bupivacaine or thoracic epidural analgesia. The study involves comparing these two methods to manage pain effectively.