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A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Study of Investigational Medication for Cancer Patients

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the use of an investigational medication in patients with solid tumors. The purpose of this study is to evaluate the investigational medication when used alone and in combination with another treatment.

The study evaluates the safety and tolerability of the investigational medication, as well as its effects on the body and its ability to fight tumors. It looks at how the investigational medication behaves in the body and its overall effectiveness.

  • Who can participate: Adults with advanced solid tumors who have no remaining treatment options and can swallow pills may qualify.
  • Study details: Participants will take the investigational medication alone or with another treatment. Some participants may receive a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.
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Study details
    Solid Tumours
    Sarcoma
    HNSCC
    Non Small Cell Lung Cancer
    Head and Neck Squamous Cell Carcinoma
    NSCLC
    Pancreatic Adenocarcinoma
    Colorectal Cancer (CRC)
    Myxofibrosarcoma (MFS)
    Solitary Fibrous Tumors
    Dedifferentiated Liposarcoma
    Undifferentiated Pleomorphic Sarcoma (UPS)

NCT06789172

Epkin

17 April 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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