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Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

Study of Treatment for Resectable Pancreatic Cancer

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates pancreatic cancer. It focuses on using a combination of FOLFIRINOX chemotherapy and pembrolizumab, an investigational medication, before surgery.

The purpose of this study is to evaluate the safety and effectiveness of this treatment combination. It will look at how well the treatment works and the immune response in patients.

  • Who can participate: Adults 18 years and older with localized adenocarcinoma of the pancreas that is resectable can participate. Participants must not have received prior chemotherapy or radiation for pancreatic cancer and must have an ECOG performance status of 0-1.
  • Study details: Participants will receive FOLFIRINOX and pembrolizumab before surgery. After surgery, they will continue with chemotherapy and pembrolizumab. Pembrolizumab is an investigational medication, and participants will receive it in cycles.
  • Study timelines: The study will last 3.5 years.
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Study details
    Pancreatic Ductal Adenocarcinoma

NCT05132504

Baylor College of Medicine

31 July 2026

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