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A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

Study on Safety and Effectiveness of Investigational Treatments for Unresectable Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 1/2

This study investigates unresectable locally advanced or metastatic solid tumors. It evaluates the safety and tolerability of different investigational treatments for various tumor types, including clear cell renal cell cancer, pancreatic ductal adenocarcinoma, colorectal cancer, and urothelial carcinoma.

The study focuses on assessing the safety, tolerability, and imaging characteristics of investigational medications. It also evaluates the effectiveness of these treatments in managing the condition.

  • Who can participate: Participants must have unresectable locally advanced or metastatic solid tumors such as clear cell renal cell cancer, pancreatic ductal adenocarcinoma, or colorectal cancer. They should have received prior treatments and have measurable disease.
  • Study details: Participants will receive investigational medications to evaluate their safety, tolerability, and effectiveness. Some participants may receive a placebo.
Study details
    Clear Cell Renal Cell Cancer (ccRCC)
    Pancreatic Ductal Adenocarcinoma (PDAC)
    Colorectal Cancer (CRC)
    Urothelial Carcinoma (UC)
    Indeterminate Renal Mass (IDRM)
    Muscle Invasive Bladder Cancer (MIBC)
    Head and Neck Cancer (H&N)
    Triple Negative Breast Cancer (TNBC)
    Squamous Non-Small Cell Lung Cancer (NSCLC)

NCT05706129

Lumara Bio Oncologics GmbH

15 August 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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