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ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer

The Study Investigates Total vs Partial Pancreatic Removal for Pancreatic Head Cancer

Recruiting
18 years and older
All
Phase N/A

This study investigates the effects of total versus partial pancreatic removal for patients with cancer of the pancreatic head. The purpose of this study is to understand if removing the entire pancreas is a better choice than just removing part of it.

The study evaluates overall survival and quality of life for patients undergoing these procedures. It examines if total removal can prevent complications like pancreatic leakage and improve outcomes without affecting quality of life.

  • Who can participate: Adults aged 18 and older with suspected or confirmed resectable pancreatic ductal adenocarcinoma, distal cholangiocarcinoma, or ampullary cancer may participate. Participants must be at high risk for postoperative pancreatic fistula and provide written consent.
  • Study details: Participants will undergo either total or partial pancreas removal surgery. They will complete questionnaires and provide blood samples.
Study details
    Pancreatic Cancer

NCT06801899

Insel Gruppe AG, University Hospital Bern

22 August 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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