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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Evaluating FMC-376 for KRAS G12C Mutated Solid Tumors

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates KRAS G12C mutated solid tumors. Participants will be evaluated using the investigational medication FMC-376.

The purpose of this study is to evaluate the safety and effectiveness of the investigational medication FMC-376 in participants with advanced solid tumors. The study will focus on understanding how well the investigational medication works and its potential side effects.

  • Who can participate: Participants must have advanced solid tumors with a KRAS G12C mutation and a performance status of 0 or 1. They should have adequate organ function.
  • Study details: Participants will receive the investigational medication FMC-376. Some participants may receive a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.
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Study details
    Advanced Solid Tumors With KRAS G12C Mutations
    Solid Tumor
    Adult
    Unresectable Solid Tumor
    Metastatic Solid Tumor
    Non Small Cell Lung Cancer
    Colorectal Cancer
    KRAS G12C
    Pancreatic Cancer

NCT06244771

Frontier Medicines Corporation

31 July 2026

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