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Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

Study of Investigational RAS(ON) Inhibitor for Metastatic Pancreatic Adenocarcinoma

Recruiting
18 years and older
All
Phase 3

This study investigates metastatic pancreatic adenocarcinoma. It evaluates the safety and efficacy of an investigational medication used alone or with chemotherapy compared to standard chemotherapy.

The study focuses on assessing whether the investigational medication improves progression-free survival and overall survival. It looks at how the medication performs as a first-line treatment.

  • Who can participate: Adults 18 years and older with confirmed metastatic pancreatic adenocarcinoma can participate, with an ECOG performance status of 0 or 1 and adequate organ function.
  • Study details: Participants will receive either the investigational RAS(ON) inhibitor alone, the investigational RAS(ON) inhibitor with chemotherapy, or standard chemotherapy.
Study details
    Pancreatic Cancer
    Pancreatic Cancer Metastatic
    PDAC
    PDAC - Pancreatic Ductal Adenocarcinoma
    Pancreatic Ductal Adenocarcinoma (PDAC)
    Pancreatic Adenocarcinoma Metastatic
    Pancreatic Adenocarcinoma
    Pancreatic Adenosquamous Carcinoma

NCT07491445

Revolution Medicines, Inc.

5 September 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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