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M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

Investigating an Investigational Medication Alone and with an Investigational Medication or Chemotherapy in Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the use of M0324 in treating selected advanced solid tumors. The purpose of this study is to evaluate M0324 as a monotherapy and in combination with other treatments.

The study evaluates the safety and potential benefits of M0324, including its effects on the body and how it interacts with other medications.

  • Who can participate: Participants must have certain advanced or metastatic solid tumors that overexpress MUC-1. Specific criteria apply for untreated metastatic pancreatic ductal adenocarcinoma.
  • Study details: Participants will receive an investigational medication alone or in combination with an investigational medication or mFOLFIRINOX. A placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine, may be used in some parts of the study.
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Study details
    Advanced Solid Tumor

NCT07166601

EMD Serono Research & Development Institute, Inc.

17 October 2026

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